Key result
Plasma TDP-43 shows no association with cognitive decline, incident dementia, or Alzheimer biomarkers.
Cohort (n=1,058)
Plasma TDP-43 levels do not appear to be a useful biomarker for cognitive decline, brain MRI changes, or incident dementia in older adults.
Brain deposition of transactive response DNA-binding protein 43 (TDP-43) is a feature of neurodegenerative syndromes. We evaluated TDP-43 plasma concentrations in 1058 participants in the Cardiovascular Health Study (CHS), a population-based longitudinal cohort. The cohort was 38% male, 11% Black, had a mean age 75 years, and 261 people developed dementia over a mean of 5.5 years of follow up. Median TDP-43 levels were 211.0 pg/mL (IQR: 134.0-341.0 pg/mL). TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, with plasma AD biomarkers, with brain MRI volumes, with incident dementia, or with demographic characteristics.
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Fohner et al. (2025) conducted a cohort in Dementia (n=1,058). Plasma TDP-43 levels was evaluated on Cross-sectional or longitudinal change in cognitive scores, plasma AD biomarkers, brain MRI volumes, and incident dementia. Plasma TDP-43 levels were not associated with cross-sectional or longitudinal change in cognitive scores, incident dementia, plasma AD biomarkers, or brain MRI volumes.
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