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Document and evaluate concurrent severe interstitial pneumonitis and acute cardiopathy triggered by nivolumab immunotherapy in a patient with refractory classic Hodgkin's lymphoma.

June 5, 2022Journal of Oncology Pharmacy Practice

Nivolumab-induced pneumonitis and cardiopathy in a patient with relapsed Hodgkin's lymphoma

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LBLaurence Bonhomme‐FaivreCHU Dijon Bourgogne VGValentina GuarinoUniversity of Milan SMSrimanta Chandra MisraCentre Hospitalier de Troyes

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Case report demonstrates severe pneumonitis and cardiac hypokinesis following nivolumab therapy in relapsed Hodgkin lymphoma, highlighting the necessity of early detection of immune-related...

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Document and evaluate concurrent severe interstitial pneumonitis and acute cardiopathy triggered by nivolumab immunotherapy in a patient with refractory classic Hodgkin's lymphoma.
Case report evaluating a 65-year-old woman receiving fifth-line nivolumab monotherapy for refractory classic Hodgkin's lymphoma.
Diagnostic and monitoring assessments included chest computed tomography, pulmonary function tests, transthoracic echocardiography, cardiac MRI, and PET scans.
Following the sixth nivolumab cycle, the patient achieved complete remission but presented with NYHA stage IV dyspnea, forced expiratory volume reduced to 50%, and left ventricular ejection fraction reduced to 20%.
Discontinuation of nivolumab alongside administration of beta-blockers and ACE inhibitors resulted in clinical improvement and recovery of left ventricular ejection fraction to 48% at 4 months, maintaining complete remission at 8 months.

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Bonhomme‐Faivre et al. (2022) studied this question.

synapsesocial.com/papers/6a82614bbcee57379ab4b4fa https://doi.org/10.1177/10781552221105572

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Implication

Case report demonstrates severe pneumonitis and cardiac hypokinesis following nivolumab therapy in relapsed Hodgkin lymphoma, highlighting the necessity of early detection of immune-related...

Nivolumab-induced pneumonitis and cardiopathy in a patient with relapsed Hodgkin's lymphoma

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Cite This Study

Nivolumab-induced pneumonitis and cardiopathy in a patient with relapsed Hodgkin's lymphoma

Discussion

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Implication

Key Points

Cite This Study

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