Population
Jurkat, a human T-lymphocyte cell line
Comparison
Heterologously expressed mutant Kv1.3 subunits… vs Endogenous wild-type (WT) Kv1.3 subunits
Design
Preclinical
Authors
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Kv1.3 assembly follows binomial kinetics in models; leaves open whether temporal expression regulates native cardiac K+ channel diversity.
Diversity of K+ channel subtypes in a cell is regulated by the degree of temporal overlap and the kinetics of subunit expression rather than spatial segregation.
Panyi et al. (1996) studied this question.
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