What question did this study set out to answer?

To compare the mucoadhesive properties of chitosan-coated liposomes versus liposomes-in-chitosan hydrogels across varying molecular weights, concentrations, and environmental conditions for localized vaginal drug delivery.

September 23, 2025Journal of Drug Delivery Science and TechnologyOpen Access

Formulation matters: Assessment of the correlation between mucoadhesiveness and type of chitosan formulation for vaginal application

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Authors

SMSilje MørkUiT The Arctic University of Norway CECharlotte Eilertsen NŠNataša Škalko‐BasnetCentre for Arctic Gas Hydrate, Environment and Climate

Discussion

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Implication

In vitro study demonstrates superior mucoadhesiveness for liposomes-in-chitosan hydrogels under vaginal conditions, highlighting formulation impacts on localized drug retention.

Key Points

To compare the mucoadhesive properties of chitosan-coated liposomes versus liposomes-in-chitosan hydrogels across varying molecular weights, concentrations, and environmental conditions for localized vaginal drug delivery.
Formulated liposomes averaging 135 nm in size (baseline zeta potential -2.78 mV) either as chitosan-coated vesicles or incorporated within chitosan hydrogels.
Tested low- and medium-molecular-weight chitosan across four concentrations (0.1%, 0.3%, 0.6%, and 1.0%) under physiological conditions including varying pH, biological fluids, and temperature.
Evaluated mucoadhesive interactions by monitoring changes in zeta potential and rheological viscosity profiles after mixing with mucin.
Surface charge increased from -2.78 mV upon coating or hydrogel embedding, confirming chitosan integration and appropriate rheological profiles for vaginal administration.
Mucoadhesiveness displayed a positive correlation with chitosan concentration and was significantly modulated by chitosan molecular weight, pH, and temperature.
Liposomes-in-chitosan hydrogel formulations exhibited superior mucoadhesive potential compared to chitosan-coated liposomal suspensions.

Cite This Study

Mørk et al. (2025) studied this question.

synapsesocial.com/papers/6a8262e11fb4be735b3f1684 https://doi.org/10.1016/j.jddst.2025.107564

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Implication

In vitro study demonstrates superior mucoadhesiveness for liposomes-in-chitosan hydrogels under vaginal conditions, highlighting formulation impacts on localized drug retention.

Formulation matters: Assessment of the correlation between mucoadhesiveness and type of chitosan formulation for vaginal application

Discussion

Member takes

Implication

Key Points

Cite This Study

Formulation matters: Assessment of the correlation between mucoadhesiveness and type of chitosan formulation for vaginal application

Discussion

Member takes

Implication

Key Points

Cite This Study

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