Why the study?
Does homocysteine-lowering treatment with folic acid plus pyridoxine improve blood pressure, brachial artery endothelium-dependent vasodilation, or carotid artery stiffness in clinically healthy siblings of patients with premature atherothrombotic disease?
Population
158 clinically healthy siblings of patients with premature atherothrombotic disease
Comparison
Folic acid plus pyridoxine for 2 years vs Placebo
Design
RCT, randomized, placebo-controlled
Follow-up
2 years
Authors
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Modest BP reduction with folic acid plus pyridoxine in high-risk siblings; extends homocysteine-lowering effects to BP without improving endothelial function or stiffness.
Does homocysteine-lowering treatment with folic acid plus pyridoxine improve blood pressure, brachial artery endothelium-dependent vasodilation, or carotid artery stiffness in clinically healthy siblings of patients with premature atherothrombotic disease?
Long-term homocysteine-lowering therapy with folic acid and pyridoxine lowers blood pressure but does not improve endothelial function or arterial stiffness in healthy individuals with a family history of premature atherothrombotic disease.
Dijk et al. (2001) studied this question.
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