Effect of Food Intake on Hemodynamic Parameters during the Tilt-Table Test in Patients with Postural Orthostatic Tachycardia Syndrome

Mario Habek; Berislav Ruška; Luka Crnošija; Ivan Adamec; Anamari Junaković; Magdalena Krbot Skorić

doi:10.3988/jcn.2019.15.2.205

January 1, 2019Journal of Clinical NeurologyOpen Access

Effect of Food Intake on Hemodynamic Parameters during the Tilt-Table Test in Patients with Postural Orthostatic Tachycardia Syndrome

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Why the study?

The study was conducted to determine the effect of food intake on heart rate in postural orthostatic tachycardia syndrome (POTS).

Does food intake alter hemodynamic parameters during the tilt-table test in patients with postural orthostatic tachycardia syndrome?

Structured PICO

Does food intake alter hemodynamic parameters during the tilt-table test in patients with postural orthostatic tachycardia syndrome?

P

Population

51 participants, including 41 consecutive patients referred for tilt-table testing with a sustained HR increment of ≥30 beats/min within 10 min of standing or head-up tilting (mean age 29.74±10.61 years, 29 females) and 10 healthy controls (mean age 24.25±2.25 years, 6 females).

I

Intervention

Ingestion of 400 mL liquid meal replacement (Nutridrink Multi Fibre, 300 kcal) during a 5-phase tilt-table test protocol.

C

Comparator

Hemodynamic parameters before the meal (within-subject comparison) and healthy controls.

O

Outcome

Difference in heart rate for standing vs. supine (ΔHR) before and after the meal.surrogate

Limitations

Possibility of selection bias
Possibility that some patients in group C recovered by the time they were tested for the second time
Did not classify patients according to POTS subtypes (e.g., neuropathic or hyperadrenergic)

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Implication

Food intake significantly alters the results of the tilt-table test in POTS patients, suggesting that performing the test after a controlled meal might increase diagnostic sensitivity and specificity.

Abstract

BACKGROUND AND PURPOSE: The aim of this study was to determine the effect of food intake on the heart rate (HR) in postural orthostatic tachycardia syndrome (POTS). METHODS: =16). Group D consisted of 10 healthy subjects. RESULTS: <0.0001, respectively). When we pooled patients (according to their symptoms) from group A and B into a POTS group and from group C and D into a non-POTS group, an increase in HR of 25 beats/min before the meal had a sensitivity of 92.0% and a specificity of 80.8%. After the meal, an increase in HR of 30 beats/min had a sensitivity of 96.0% and a specificity of 96.2%. CONCLUSIONS: Food intake can significantly alter the results of the tilt-table test and so should be taken into account when diagnosing POTS.

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Cite This Study

Habek et al. (2019) studied this question.

synapsesocial.com/papers/6a8263197db08d7cfd3f1da0 https://doi.org/10.3988/jcn.2019.15.2.205

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Effect of Food Intake on Hemodynamic Parameters during the Tilt-Table Test in Patients with Postural Orthostatic Tachycardia Syndrome

Figures

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Effect of Food Intake on Hemodynamic Parameters during the Tilt-Table Test in Patients with Postural Orthostatic Tachycardia Syndrome

Figures

Structured PICO

Limitations

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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