Is fatigue in primary biliary cirrhosis cured by transplantation?

The name primary biliary cirrhosis (PBC) was coined when the disease was mostly diagnosed in its late cirrhotic stage [1]. Today, PBC must be considered a historic misnomer, as the disease nowadays presents usually many years or decades prior to the development of cirrhosis, and with timely diagnosis and adequate treatment, the majority of patients never reach the stage of cirrhosis [2–4]. It is considered an autoimmune disease characterized by non-suppurative destructive cholangitis, and it is thus considered a disease of the small intra-hepatic bile ducts.