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When DNA duplexes are preformed in water, then DNA-templated synthesis (DTS) can take place efficiently and sequence-specifically in organic solvents with low or minimal water content. This simple method enables reactions that are inaccessible in water, such as pyrrolidine-catalyzed aldol condensation, to be performed. The conditions needed to perform DTS in organic solvents also support DNA-templated reactions that are known to take place in aqueous solution.
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Rozenman et al. (2006) studied this question.
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