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May 27, 2008Pharmacology

The Effects of Pharmacologic Agents on Myocardial Sodium (Na + ) and Potassium (K + ) Stimulated ATPase

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Authors

SSShuang‐Shuang SongArmy Medical UniversityJSJ. ScheuerAlbert Einstein College of Medicine

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Implication

In vitro ATPase effects require validation in intact models; leaves open clinical relevance for myocardial ion handling.

Key Points

  • Investigate the direct effects of cardiovascular and diuretic pharmacologic agents on myocardial sodium- and potassium-stimulated ATPase activity.
  • Assayed myocardial tissue preparations to quantify sodium- and potassium-stimulated ATPase enzyme activity.
  • Tested enzymatic responses to cardiovascular agents, including digitalis, quinidine, procaine amide, propranolol, chlorothiazide, and ethacrynic acid.
  • Myocardial sodium-potassium ATPase activity is altered upon exposure to specific antiarrhythmic, inotropic, and diuretic compounds.
  • Identified distinct inhibitory interactions on myocardial ATPase that characterize the biochemical behavior of cardiovascular agents during conditions like ischemia.

Cite This Study

Song et al. (2008) studied this question.

synapsesocial.com/papers/6a826bdd70df46ce3ea2152chttps://doi.org/10.1159/000135967
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