Why the study?
Preoperative differential diagnosis of lipoma or atypical lipomatous tumor/well-differentiated liposarcoma can provide important information for treatment decisions.
Can cytological analysis and MDM2 FISH differentiate between lipoma and atypical lipomatous tumor/well-differentiated liposarcoma?
Can cytological analysis and MDM2 FISH differentiate between lipoma and atypical lipomatous tumor/well-differentiated liposarcoma?
Cytological evaluation of multinucleated cells and pleomorphism, along with MDM2 amplification, can aid in the preoperative differential diagnosis of lipoma and ALT/WDL.
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May aid preoperative lipoma vs ALT/WDL differentiation; leaves open prospective validation of cytotechnologist-MDM2 concordance.
Sugiyama et al. (2022) studied this question.
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