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What is the immunohistochemical staining profile of spindle cell lipoma?
What is the immunohistochemical staining profile of spindle cell lipoma?
Spindle cell lipomas are strongly CD34 positive, which can aid in differentiating them from other soft tissue neoplasms when using a broad panel of immunostains.
May aid differentiation of spindle cell lipoma via CD34 staining; leaves broader validation open from case reports alone.
Spindle cell lipoma (SCL) is an uncommon soft tissue neoplasm that may provide diagnostic difficulty to the histopathologist. Four retrospectively identified SCLs were evaluated immunohistochemically with a broad panel of antibodies (CD34, factor XIIIa, S-100, actin and factor VIII). All four SCLs were strongly CD34 positive (95 to 100% of cells) and focally factor XIIIa positive (average 16% of cells). Tumor cells were S-100, actin and factor VIII negative. Dermatofibrosarcoma protuberans, neurofibroma, schwannoma and angiolipoma are CD34 positive tumors that have some similar histologic features to SCL and may be considered in the differential diagnosis. Differentiation is possible using a broad panel of immunostains and routine diagnostic criteria.
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Templeton et al. (1996) studied this question.
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