Why the study?
Atrial fibrillation is closely associated with cardiovascular disease, but the risk of AF associated with cardiovascular risk factors has not been well elucidated.
Do cardiovascular risk factors increase the incidence of atrial fibrillation in the general population?
Do cardiovascular risk factors increase the incidence of atrial fibrillation in the general population?
Adverse cardiovascular risk factors such as smoking, diabetes, and hypertension are significantly associated with an increased risk of incident atrial fibrillation, whereas dyslipidemia is not.
May inform AF prevention strategies in at-risk patients; leaves open whether risk-factor modification reduces incidence in trials.
Background: The most prevalent sustained arrhythmia in medical practice, atrial fibrillation (AF) is closely associated with a high risk of cardiovascular disease. Nevertheless, the risk of AF associated with cardiovascular risk factors has not been well elucidated. We pooled all published studies to provide a better depiction of the relationship among cardiovascular risk factors with AF. Methods: Studies were searched in the MEDLINE, Web of Science, and EMBASE databases since initiation until January 15, 2022. Prospective cohort studies assessing the relationship a minimum of single cardiovascular risk factors to AF incidence were included if they contained adequate data for obtaining relative risks (RR) and 95% confidence intervals (CI). Random-effects models were utilized to perform independent meta-analyses on each cardiovascular risk factor. PROSPERO registry number: CRD42022310882. Results: for increase in body mass index, 1.19 (95% CI, 1.10-1.28) for former smokers, 1.23 (95% CI, 1.09-1.38) for current smokers, 1.31 (95% CI, 1.23-1.39) for diabetes mellitus, 1.68 (95% CI, 1.51-1.87) for hypertension, and 1.12 (95% CI, 0.95-1.32) for dyslipidemia. Interpretation: Adverse cardiovascular risk factors correlate with an increased risk of AF, yet dyslipidemia does not increase the risk of AF in the general population, potentially providing new insights for AF screening strategies among patients with these risk factors. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, PROSPERO identifier (CRD42022310882).
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Wu et al. (2023) studied this question.
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