Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity

BACKGROUND: Melatonin (MLT) is a potent antioxidant molecule that is shown to have a beneficial effect in various pathological situations, due to its action against free radicals. AIM: ) induced liver injury in rats in terms of oxidative stress, reticular stress, and cell damage. METHODS: wk). RESULTS: glucose-regulated protein 78 and activating transcription factor 6, as well as of heat shock factor 1 and heat shock protein 70. CONCLUSION: -induced liver injury, since it reduces oxidative stress, restores zinc levels, and modulates endoplasmic reticulum stress.