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THE ECHO viruses, though recognized only recently, are clearly capable of producing a varied spectrum of clinical illness. Melnick and Sabin,1 in observations based on recent epidemic outbreaks of infection, have emphasized the development of different clinical syndromes which were attributed to the specific type of ECHO virus responsible for the infection. On the other hand, evaluation of sporadic infections due to these viruses, as well as a general comparison of clinical features based upon epidemic outbreaks, points to predominance of common group features shared not only by most types of ECHO viruses but also by the entire group of . . .
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Sanford et al. (1959) studied this question.
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