Herpangina and Coxsackie Viruses

Since Dalldorf and Sickles1 first reported the isolation of a virus from patients suspected of having poliomyelitis by inoculation of suckling mice, a number of similar and related viruses, now known as the Coxsackie group of viruses,2 have been isolated by several groups of workers from patients with a variety of illnesses, including "aseptic meningitis,"3 nonparalytic poliomyelitis,3 unexplained fever,3 "summer grippe,"4 epidemic pleurodynia3, 5, 6 and many others.7, 8 In the summer of 1949, Huebner and his co-workers at the National Institutes of Health9 isolated Group A Coxsackie viruses from many cases of a "summer-grippe" type of illness that occurred in a localized . . .