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April 1, 1990Circulation ResearchOpen Access

Impaired prostaglandin E1/I2 receptor activity of human blood platelets in acute ischemic heart disease.

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Why the study?

Is prostaglandin E1/I2 receptor activity of blood platelets impaired in patients with acute ischemic heart disease?

Population

74 patients with acute myocardial infarction or unstable angina, 56 normal volunteers, and 7 patients with…

Design

Case-control

Follow-up

2-8 weeks

Authors

NKNighat N. KahnFox Chase Cancer CenterHMHiltrud S. MuellerThe University of Texas at AustinASAnjana SinhaRutgers, The State University of New Jersey

Discussion

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Overview

May indicate transient platelet PGE1/I2 receptor impairment in acute IHD; hypothesis-generating for thrombosis mechanisms, should not yet change practice.

Structured PICO

Is prostaglandin E1/I2 receptor activity of blood platelets impaired in patients with acute ischemic heart disease?

P
Population
74 patients with acute myocardial infarction or unstable angina, 56 normal volunteers, and 7 patients with dilated cardiomyopathy hospitalized for acute chest pain but with normal coronary arteries.
C
Comparator
Normal volunteers and patients with dilated cardiomyopathy
O
Outcome
Prostaglandin E1/I2 receptor activity (ligand binding capacity and affinity) of blood plateletssurrogate

Patients with acute ischemic heart disease exhibit a temporary impairment in platelet prostaglandin E1/I2 receptor binding capacity, which normalizes within 2-8 weeks.

Cite This Study

Kahn et al. (1990) studied this question.

synapsesocial.com/papers/6a8279bc8d8b29c30f795efchttps://doi.org/10.1161/01.res.66.4.932
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systemic and transcardiac platelet activity in acute myocardial infarction in man: resistance to prostacyclin.1985 · 95 citations
  2. 2Inhibition of Prostacyclin and Platelet Thromboxane A<sub>2</sub>after Low-Dose Aspirin1981 · 274 citations
  3. 3Clinical trials evaluating platelet-modifying drugs in patients with atherosclerotic cardiovascular disease and thrombosis.1986 · 60 citations
  4. 4Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction1980 · 2,748 citations
  5. 5Therapeutic opportunities in vasoocclusive disease.1986 · 7 citations