Population
Guinea-pig and human platelet-rich plasma
Comparison
Prostaglandin D2 combined with thromboxane… vs PGD2 alone
Design
Preclinical
Authors
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Should not change antiplatelet practice; leaves open PGD2-thromboxane receptor crosstalk for human platelet studies.
This preclinical study demonstrates that prostaglandin D2 interacts with thromboxane receptors on guinea-pig platelets, explaining its bell-shaped dose-inhibition curve for platelet aggregation.
Hamid‐Bloomfield et al. (1986) studied this question.
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