Why the study?
STING activation is initiated by cyclic dinucleotides, prompting the synthesis of structural analogues to enhance their biological properties.
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Comparison
Four novel cyclic dinucleotide analogues composed of an N-acylsulfonamide linkage
Design
Chemical synthesis and biological evaluation study
Novel N-acylsulfonamide CDN analogues enable high-yield STING probe synthesis; extends chemical diversity but leaves therapeutic translation open.
The stimulator of interferon genes (STING) protein plays a crucial role in the activation of the innate immune response. Activation of STING is initiated by cyclic dinucleotides (CDNs) which prompted the community to synthesize structural analogues to enhance their biological properties. We present here the synthesis and biological evaluation of four novel CDN analogues composed of an N -acylsulfonamide linkage. These CDNs were obtained in high overall yields via the sulfo-click reaction as a key step.
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Amador et al. (2024) studied this question.
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