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A new in vitro adult articular cartilage organ model is described. Cartilage explants from adult rabbits have maintained a maximum glycosaminoglycan synthetic rate from day 7 to day 14 of incubation and normal morphology through day 10. The metabolic and histologic stability of this articular cartilage model suggests its suitability for investigating synthesis and degradation in normal, pharmacologically altered, and diseased cartilage.
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Lane et al. (1974) studied this question.
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