Neutrophils as indicators of obesity‐associated inflammation: A systematic review and meta‐analysis

Figures

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  FIGURE 1. Mechanisms involved in obesity‐related inflammation and neutrophilia. (A) Neutrophils infiltrate into inflamed adipose tissue and support the recruitment of other immune cells. Inflamed adipose tissue releases leptin, TNFα, IL6, IL8, and IL1β and decreases the secretion of adiponectin. (B) Bone marrow myelopoiesis is enhanced by signals released by the adipose tissue and bone marrow adipocytes, activating pathways involved in the production and liberation of neutrophils to the bloodstream like TLF4, TRIF and MyD88. (C) The increase of activated circulating neutrophils results in incremented pro‐inflammatory molecules like IL8, CCL2, MMP9, MPO, and NE in blood. Routinely used parameters like absolute neutrophil count (ANC) and neutrophil‐to‐lymphocyte‐ratio (NLR) to measure blood neutrophils may serve as indicators of obesity‐related inflammation. Created with BioRender.com.

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  FIGURE 2. Flow diagram of the selection process of the studies in the meta‐analysis of ANC.

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  FIGURE 3. Flow diagram of the selection process of the studies in the meta‐analysis of NLR.

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  FIGURE 4. Forest plot of ANC in obesity.

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  FIGURE 5. Forest plot of NLR in obesity.

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  FIGURE 6. Spearman's rank correlation of ANC (A) and NLR (B) with BMI.