Key result
Higher NLR in obesity strongly correlates with hsCRP and progressive CIMT.
Why the study?
Neutrophil-to-lymphocyte ratio has been proposed as a novel biomarker for cardiovascular risks, but its relation with pro-atherogenic promoters and carotid intima-media thickness in obesity was unclear.
Observational (n=31)
No
p-value: p=0.05
In patients with obesity, the neutrophil-to-lymphocyte ratio is significantly associated with pro-inflammatory mediators, visceral adiposity, and subclinical atherosclerosis as measured by carotid intima-media thickness.
NLR was associated with inflammation and carotid thickening in obesity; leaves open its prognostic role in prospective studies.
BACKGROUND: Atherosclerosis represents a cardiovascular risk. Chronic inflammation is a key factor for atherogenic progression. Neutrophil-to-lymphocyte ratio (NLR) has been proposed as a novel biomarker for cardiovascular risks. We aimed to explore whether NLR was related to surrogate pro-atherogenic promoters driving atherogenic progression, as measured by carotid intima-media thickness (CIMT). STUDY DESIGN: Thirty-one patients with obesity candidates for bariatric surgery were recruited from Centro Médico Nacional "20 de Noviembre", ISSSTE, Mexico City. The results are part of the "CROP" study (NCT03561987). NLR was calculated from routine complete blood count, and its relation with plasma pro-inflammatory mediators (hsCRP, TNF-α and IL-1β), adipokines (adiponectin and leptin), adiposity markers (visceral adipose tissue [VAT] determined from CT scan image and VAT individual adipocyte area at histological sample) and CIMT were determined. RESULTS: Neutrophil-to-lymphocyte ratio correlated with hsCRP (Spearman's r = 0.70 [95% CI 0.46 to 0.85], P < 0.01), TNF-α (r = 0.69 [0.44 to 0.84], P < 0.0001) and adiponectin (r = -0.69 [-0.84 to -0.45], P < 0.03), as well as with VAT individual adipocyte area (r = 0.64 [0.37 to 0.81], P < 0.0001) and with VAT area (r = 0.43; [0.07 to 0.68], P < 0.01). Leptin and adiponectin showed further independent association with higher NLR (multivariate regression analysis OR 7.9 [95% CI 1.1 to 56.2] P = 0.03 and 0.1 [0.01 to 1.0] P = 0.05, respectively). Moreover, NLR distribution significantly varied between subgroups divided according to progressive CIMT (P = 0.05); whereas adiponectin and VAT adipocyte area associated with CIMT > 0.9 mm (univariate analysis OR 0.1 [0.01 to 1.0] P = 0.05 and 13.1 [1.4 to 126.3] P = 0.03, respectively). CONCLUSION: Neutrophil-to-lymphocyte ratio was related to pro-inflammatory, adiposity biomarkers and progressive subclinical atherogenesis.
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Suárez‐Cuenca et al. (2019) conducted an observational in Obesity (n=31). Neutrophil-to-lymphocyte ratio (NLR) was evaluated on Surrogate pro-atherogenic promoters driving atherogenic progression, as measured by carotid intima-media thickness (CIMT) (p=0.05). Higher neutrophil-to-lymphocyte ratio in patients with obesity correlated with hsCRP (r=0.70) and its distribution varied significantly with progressive carotid intima-media thickness (P=0.05).
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