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We have isolated an E. coli mutant in which the regulatory system controlling the synthesis of β-galactosidase has become thermolabile (Horiuchi, Horiuchi and Novick, 1961). This mutant, called E103, is derived from E102, a methionine-requiring Cavalli Hfr strain (Horiuchi, Tomizawa, and Novick, 1961).
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Horiuchi et al. (1961) studied this question.
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