Protein kinase C plays an important role in the control of junctional conductance in heart muscle, mediating the inhibitory effect of vasopressin.
Suggests PKC role in cardiac gap junction control; hypothesis-generating with no immediate clinical implications.
The effect of vasopressin on junctional conductance (gj) in isolated heart cell pairs was investigated. The results indicated that vasopressin (60 nM) causes a decrease in gj of 53% (S.E. +/- 5) (n = 10) within 15 sec. of its administration to the bath. The effect of vasopressin was dose-dependent and was suppressed by staurosporine (50 microM)--a potent inhibitor of protein kinase C. Inhibitors of protein kinase C by themselves increased gj. The results indicate that protein kinase C plays an important role in the control of gj in heart muscle.
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Walmor C. De Mello (1991) studied this question.
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