Experimental study demonstrates regional inhibition of venoconstriction by prostaglandin E1 in canine vascular beds, indicating effects do not depend on direct venodilatation.
PGE1 caused venodilatation in the isolated perfused canine gracilis muscle but not in the perfused hindpaw. Venoconstrictor responses to nerve stimulation, norepinephrine, and angiotensin were inhibited significantly and uniformly in the paw but not in the muscle. The results indicate that inhibition of venoconstrictor responsiveness by PGE1 is not associated with nor dependent upon a direct dilator action of the prostaglandin.
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Hedwall et al. (1970) studied this question.
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