Growth Hormone Signaling in the Regulation of Acid Labile Subunit

Several hormones are important for normal postnatal growth, but it is generally accepted that GH is the most important hormone in this respect. A major portion of the effects of GH on growth is mediated by IGF-I. GH stimulates growth by stimulating liver production of IGF-I, which in turn stimulates longitudinal bone growth in an endocrine manner In contrast, GH is not essential for prenatal growth and development, as shown by the existence of normal-sized infants with either congenital absence of the pituitary or deletions of the genes encoding GH or the GH receptor (GHR)