Population
In vivo transgenic murine model and human HCV-infected liver biopsies
Design
Preclinical
Authors
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Hypothesis-generating for HCV core-MTP effects in steatosis; leaves open human translation and therapeutic targeting.
HCV core protein targets microsomal triglyceride transfer protein activity and modifies hepatic VLDL assembly and secretion, providing a pathophysiological model for viral-related steatosis.
Perlemuter et al. (2002) studied this question.
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