HDL: a molecular view of the "classic" antiatherogenic lipoprotein

HDL metabolism and its relationship to atherosclerosis is a complex topic, though notable advances have been made. First, HDL clearly has an anti-atherogenic action. Second, this action is due to some fraction/s containing apoA-I but not apoA-II. Third, some of the molecular mechanisms involved in two key anti-atherogenic functions of HDL have been defined: reverse cholesterol transport and prevention of LDL oxidative modification. These advances may permit the development of effective strategies, complementing those already available, for treating and preventing atherothrombotic cardiovascular diseases.