Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1988Annals of the New York Academy of SciencesOpen Access

Role of the 15‐Lipoxygenase in the Immune Systema

View Full Paper
Ask AI
Bookmark
Share

Authors

JVJack Y. VanderhoekGeorge Washington University

Discussion

Loading...

Member takes

Implication

Laboratory analysis demonstrates cryptic 15-lipoxygenase activation in polymorphonuclear leukocytes, suggesting targeted regulation of downstream immune responses.

Key Points

  • To examine the activation state of 15-lipoxygenase in polymorphonuclear leukocytes and determine how its metabolites influence the immune response.
  • Evaluated the baseline cryptic activation state of 15-lipoxygenase in polymorphonuclear leukocytes.
  • Tested enzyme activation by applying specific cellular stimuli, including hydroxyeicosatetraenoic acids (HETEs).
  • Characterized downstream arachidonic acid metabolism and the immunomodulatory potential of the resulting products.
  • Polymorphonuclear leukocyte 15-lipoxygenase naturally resides in an inactive or cryptic state.
  • Stimulation with specific compounds, including HETEs, directly converts the inactive enzyme into a functional form that metabolizes arachidonic acid into immune-modulating metabolites.

Cite This Study

Jack Y. Vanderhoek (1988) studied this question.

synapsesocial.com/papers/6a828dda0f52607ca18ad733https://doi.org/10.1111/j.1749-6632.1988.tb38547.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Emerging cellular functions of the lipid metabolizing enzyme 15‐Lipoxygenase‐12018 · 74 citations
  2. 2Leukocyte-type 12/15-lipoxygenase is essential for timely inflammation-resolution and effective tissue regeneration following skeletal muscle injury2025 · 9 citations
  3. 312/15-lipoxygenase orchestrates murine wound healing via PPARγ-activating oxylipins acting holistically to dampen inflammation2025 · 11 citations
  4. 4Fatty acids negatively regulate platelet function through formation of noncanonical 15‐lipoxygenase‐derived eicosanoids2023 · 12 citations
  5. 5Lipoxygenase Pathways in the Regulation of Vascular Inflammation and Its Resolution2026