Why the study?
PDE4D7 expression is significantly associated with prostate cancer progression, but whether other genes in the PDE4D coding region were also associated remained unknown.
Novel PDE4D7-associated genes in the PDE4D coding region represent putative prostate cancer biomarkers and may have mechanistic roles in disease progression.
These sequences may serve as prostate cancer biomarkers; leaves open validation and mechanistic roles pending prospective studies.
Aim: PDE4D7 expression is significantly associated with prostate cancer (PCa) progression, representing an attractive prognostic biomarker. We sought to determine whether other genes in the PDE4D coding region were associated. Patients & methods: RNA from biopsy punch samples of resected tumor tissue was analyzed via RNA sequencing. RT-qPCR was used to determine PDE4D7 score. Results: Numerous genomic sequences within the PDE4D coding region on Chr5q12 revealed similar mRNA expression profiles to PDE4D7. PART1 had a significantly similar expression pattern to PDE4D7 across samples, correlating with disease progression. However, many other genes also exhibited matched expression to PDE4D7, including miRNAs and lncRNAs. Conclusion: These novel PDE4D7-associated genes, many of which are previously uncharacterized in cancer, represent putative PCa biomarkers and could have mechanistic roles in PCa progression.
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Gulliver et al. (2023) studied this question.
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