Why the study?
PDE4D7 expression is diminished during progression of PCa and has been proposed as a prognostic biomarker.
Novel PDE4D7 associated genes, including miRNAs and lncRNAs, represent putative prostate cancer biomarkers and may have mechanistic roles in progression.
PDE4D7-coexpressed genes may represent prostate cancer biomarkers; hypothesis-generating in animal models and requires human validation.
PDE4D7 expression is diminished during progression of PCa and the phosphodiesterase has been proposed as a prognostic biomarker. RNA sequencing of PCa tissue identified sequences in the PDE4D coding region on Chr5q12 exhibiting similarities in mRNA expression profile to PDE4D7. As previously identified, PART1 had a significantly similar expression pattern to PDE4D7 across samples. However, other genes also matched expression to PDE4D7, including miRNAs and lncRNAs. These novel PDE4D7 associated genes represent putative PCa biomarkers and could have mechanistic roles in PCa progression.
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Gulliver et al. (2022) studied this question.
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