Why the study?
Does dual therapy combining PDE4 inhibition with Ca2+ channel antagonism provide an effective treatment strategy for patients with severe COPD?
Does dual therapy combining PDE4 inhibition with Ca2+ channel antagonism provide an effective treatment strategy for patients with severe COPD?
Dual therapy combining PDE4 inhibition with calcium channel antagonism is proposed as a novel strategy for managing severe COPD.
Should not yet change severe COPD management; hypothesis-generating for dual PDE4-Ca2+ channel inhibition.
Targeting type 4 phosphodiesterase (PDE4) for treatment of COPD has multilevel benefits to patients by reducing inflammation, relieving bronchoconstriction, and improving pulmonary circulation. The isoenzyme-specific narrow spectrum PDE4 inhibitors such as cilomilast and roflumilast may have limited clinical efficacy in managing severe and very severe COPD. Development of dual therapy by combining PDE4 inhibition with Ca2+ channel antagonism may introduce an effective novel armory for physicians to manage patients with severe COPD.
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Wang et al. (2006) studied this question.
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