Antihemophilic factor (AHF) concentrates contain noncellular particulate material which is retained by a screen filter of 40 mu pore size. This material is composed in part of IgG, fibrinoprotein, and cold insoluble globulin. The clinical significance of this material is uncertain, but a possible association with pulmonary and cerebral microemboli is suggested.
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Eyster et al. (1978) studied this question.
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