Clinical Trial of Chlorhexidine and Diaminodiphenylsulphone in Superficial Ocular Infections

This compound has a wide range of bacteriostatic activity against both Gram-positive and Gram-negative organisms and is of low toxicity. The development of bacterial resistance to chlorhexidine has. not been demonstrated. It is now used extensively for general antisepsis, but until recently its application in the conjunctival sac has been limited by the irritant nature of the diacetate salt commonly employed. Recently a less. irritant but still soluble salt, chlorhexidine gluconate, has become available. This may be used in strengths of up to 0-2 per cent. as against 0 05 per cent.. for the diacetate compound.