Why the study?
Does lactic acid addition improve force production in isolated rat soleus muscles exposed to elevated extracellular potassium?
Does lactic acid addition improve force production in isolated rat soleus muscles exposed to elevated extracellular potassium?
Acidification counteracts the depressing effects of elevated extracellular potassium on muscle excitability and force, suggesting acidosis may protect against muscle fatigue rather than cause it.
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Acidosis may protect against K+-induced force loss in isolated muscle; hypothesis-generating for fatigue mechanisms, needs in vivo confirmation.
Paoli et al. (2001) studied this question.
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