Electrical stimulation of cultured chick embryo skeletal muscle cells elicits a protein synthetic response characteristic of in vivo skeletal muscle hypertrophy.
Offers cellular model of hypertrophy-like protein synthesis; leaves open translation to mammalian muscle or clinical use.
When cultures of skeletal muscle cells of the chick embryo are subjected to repetitive, electrical stimulation, the contractions increase the amount of protein produced by these cells. The increase is greater for contractile proteins such as myosin heavy chain than for total cellular protein. This demonstrates that in a culture system of skeletal muscle cells that have differentiated in the absence of innervation, one can elicit the protein synthetic response associated with skeletal muscle hypertrophy in vivo.
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Brevet et al. (1976) studied this question.
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