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Cytochrome. The most outstanding contribution to our knowledge of the mechanism of the reaction in vivo of substrates with molecular oxygen was the theory advanced by The reaction between substrate and oxygen was thus regarded as a process in two stages, one of which concerns the reduc- tion of cytochrome and the other the oxidation of cytochrome. The experimental basis for this theory is briefly the following:
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Ogston et al. (1935) studied this question.
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