January 1, 2004Journal of Pharmacological SciencesOpen Access

Hypotonic Stress Increases Efficacy of Rilmakalim, but Not Pinacidil, to Activate ATP-Sensitive K+ Current in Guinea Pig Ventricular Myocytes

View Full Paper

Ask AI

Bookmark

Population

Guinea pig ventricular myocytes (n=7)

Comparison

Rilmakalim and pinacidil under hypotonic stress vs Isotonic solution

Design

Preclinical

Authors

IKIvan KocićGdańsk Medical University YHYuji HiranoNational Center for Geriatrics and Gerontology MHMasayasu HiraokaElectrophysiology

Discussion

Member takes

Implication

Rilmakalim's osmotic enhancement in guinea pig myocytes extends K(ATP) research; leaves open human cardiac translation.

Structured PICO

Population

Guinea pig ventricular myocytes (n=7)

Intervention

Rilmakalim and pinacidil under hypotonic stress (about 100 mOsm difference due to mannitol concentrations)

Comparator

Isotonic solution

Outcome

Activation of ATP-sensitive K(+) current (Emax and pD2)surrogate

Osmotic stress increases the efficacy of rilmakalim to activate K(ATP) channels in guinea pig ventricular myocytes via interaction with actin filaments.

Cite This Study

Kocić et al. (2004) studied this question.

synapsesocial.com/papers/6a8290cb4699435f741e0af2 https://doi.org/10.1254/jphs.fp0030477

View Full Paper

Ask AI

Bookmark

Hypotonic Stress Increases Efficacy of Rilmakalim, but Not Pinacidil, to Activate ATP-Sensitive K+ Current in Guinea Pig Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hypotonic Stress Increases Efficacy of Rilmakalim, but Not Pinacidil, to Activate ATP-Sensitive K+ Current in Guinea Pig Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider