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Iron has varied importance in the biological activity of cells. Supraphysiologic levels of iron are deleterious for cellular survival. Besides, iron also plays a significant role in the immunologic surveillance. Anemia of chronic disease (ACD) is the anemia that is caused not due to marrow deficiency of iron, but due to an underlying chronic inflammatory disease. ACD is caused due to factors, which impede the availability of iron stores in the body. Identification of the condition requires meticulous hematologic work up. Therapy for ACD involves manipulating the inflammatory process and the resultant inflammatory cytokines, which are a major source for inhibition of iron availability.
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Santosh et al. (2015) studied this question.
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