C-reactive protein and glycemic control in adults with type 2 diabetes mellitus

Objective: To find a correlation between glycemic control and C-reactive protein (CRP) in patients with type 2 diabetes mellitus (T2DM) and to assess if good control of glycosylated hemoglobin (HbA1c) decreases the CRP values. Materials and Methods: The study included 50 patients with T2DM whose detailed clinical history and physical examination were done. Evaluation of parameters such as height, weight, waist–hip ratio, body mass index, Hb, total blood count, differential count, erythrocyte sedimentation rate, blood urea, and serum creatinine was done. Urine examination and blood samples were obtained for analysis of CRP, fasting blood sugar, postprandial blood sugar, HbA1c, serum total cholesterol, serum triglycerides, high-density lipoprotein, and low-density lipoprotein. CRP was correlated with HbA1 statistically. Result: The study reveals that levels of CRP and HbA1c were bi-directionally correlated with P < 0.05. Better glycemic control is leading to the reduction in HbA1c also resulted in a decrease in CRP levels (P = 0.000). Conclusion: There exists a strong correlation between HbA1c and CRP in T2DM. Hence, CRP is an additional marker of better glycemic control.