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After injection of 0.1mg of synthetic luteinizing hormone-releasing hormone (LH-RH), levels of FSH and/or LH rise significantly in the serum of normal prepubertal children. LH-RH stimulation may be used to evaluate pituitary gonadotropic reserve in prepubertal patients with various hypothalamo-hypophysial and gonadal disorders.
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Job et al. (1972) studied this question.
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