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Synthetic LRF (single IV 150 μg dose) elicited a prompt increase in circulating LH in all 7 male subjects tested. The mean maximal rise to greater than 8-fold basal levels was reached within 20–30 min. A concomitant but quantitatively smaller FSH release was observed. Variability in response between individuals was not related to body surface area or age.
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YEN et al. (1972) studied this question.
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