Why the study?
Do high values of blood lipid peroxides (TBA-RS) predict vascular ischemia in high-risk patients with TIA?
Do high values of blood lipid peroxides (TBA-RS) predict vascular ischemia in high-risk patients with TIA?
High blood values of lipid peroxides (TBA-RS) may serve as a predictive marker for future vascular ischemic events in high-risk TIA patients.
TBA-RS elevation was associated with vascular events in TIA patients; hypothesis-generating and should not yet change risk stratification.
The clinical meaning of high values of blood lipid peroxides, assessed as thiobarbituric acid reactive substances (TBA-RS), was investigated in 19 selected high risk patients with transient ischemic attacks (TIA). Patients were checked every 3-6 months and followed-up for 3 years. 8 patients experienced further vascular episodes, 4 having minor stroke and 4 TIA; one of the latter died from myocardial infarction. Unlike blood cholesterol and glucose. TBA-RS values discriminated patients with vascular episodes: they, indeed, showed significant higher values of TBA-RS. Discriminant analysis further indicated that TBA-RS levels differentiate patients with and without vascular accidents, suggesting that high blood values of lipid peroxides could represent a predictive sign of vascular ischemia.
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Alessandri et al. (1991) studied this question.
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