Population
Synthetic peptide substrates and human rhinovirus 2 proteinase 2A expressed in Escherichia coli
Design
Preclinical
Authors
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Characterizes rhinoviral 2A cleavage requirements in vitro; leaves open applicability to human replication and antiviral design.
The sequence Thr-X-Gly may form the basis of the cellular cleavage site processed by rhinoviral 2As during viral replication, supporting its classification as a new class of cysteine proteinases.
Sommergruber et al. (1992) studied this question.
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