Case report demonstrates rare adenosquamous prostate cancer with near-normal PSA in a 73-year-old male, highlighting the need for aggressive surgery for refractory disease.
Adenosquamous carcinoma (ASC) of the prostate is an extremely rare, aggressive histological subtype of prostate cancer. We report one such case here of a 73-year-old man with prostatic malignancy with a combination of squamous and glandular components. Immunohistochemistry with p40, AMACR and HMWCK corroborated the diagnosis of ASC. The squamous component being refractory, is better amenable to aggressive surgery, highlighting the importance of recognising this entity. Bony metastasis was not seen in this patient. Serum PSA was near normal.
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Sreeram et al. (2023) studied this question.
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