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The results of these experiments indicate that basal levels of activity of hepatic microsomal drug metabolizing enzyme systems from various rabbit strains can vary as much as 20-fold in the strains studied. This is particularly true of hexobarbital, amphetamine, and aminopyrine metabolism where the widest variations were observed. Relatively little strain variation was seen in the basal metabolism of chlorpromazine. The wild rabbits and California rabbits exhibited the greatest differences from other rabbit strains in basal hepatic drug metabolism.
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Cram et al. (1965) studied this question.
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