Why the study?
Does hormonal replacement therapy and ovulation induction enable successful pregnancy in a woman with panhypopituitarism?
Does hormonal replacement therapy and ovulation induction enable successful pregnancy in a woman with panhypopituitarism?
Hormonal replacement therapy and ovulation induction can result in successful pregnancy in women with panhypopituitarism.
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May support fertility treatment in panhypopituitarism; hypothesis-generating case report requiring larger studies before practice change.
BACKGROUND Pregnancy in a woman with hypopituitarism from a suprasellar germinoma is rare. CASE A 27-year-old woman presented with panhypopituitarism from a suprasellar germinoma. She had diabetes insipidus, hypothyroidism, adrenal cortex dysfunction, and hypogonadotropic ovarian failure. When treated with thyroxin, cortisol, antidiuretic hormone, human menopausal gonadotropin, and human chorionic gonadotropin, she conceived and gave birth to healthy twins. CONCLUSION Hormonal replacement therapy and ovulation induction resulted in a successful pregnancy in a woman with panhypopituitarism.
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Kitajima et al. (2003) studied this question.
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