Why the study?
Does the administration of HES 6% and ondansetron reduce the incidence of hypotension in parturients undergoing caesarean section under spinal anaesthesia?
Does the administration of HES 6% and ondansetron reduce the incidence of hypotension in parturients undergoing caesarean section under spinal anaesthesia?
The combination of HES 6% and ondansetron appears to reduce the incidence of arterial hypotension in parturients undergoing caesarean section under spinal anaesthesia compared to historical literature.
May support combined HES-ondansetron prophylaxis; leaves open confirmation in randomized trials.
The purpose of this retrospective study was to estimate the frequency of hypotension and bradycardia in parturients undergoing caesarean section, after the introduction of a protocol providing for the administration of colloids (HydroxyEthylStarch, HES 6%) 500 ml for hypotension prevention after spinal anaesthesia and the administration of Ondansetron (8 mg) for nausea and vomiting prevention. We reviewed the anaesthesiology records of the patients who underwent to caesarean section in spinal anaesthesia, in Nocera Inferiore Hospital (Salerno), between January 2012 and May 2012. 54 patients were examined. Retrospective examination of the records showed a 16,6% incidence of systolic hypotension, and 25,9% of diastolic hypotension. The average consumption of Ephedrine was 5.91 mg. Only 4 (7,4%) patients had an episode of bradycardia, HR < 60, no < 58.The association HES 6% plus Ondansetron seems to reduce the incidence of arterial hypotension in parturients undergoing caesarean section, compared to the incidence of hypotension reported in literature.
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A 2012 study studied this question.
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