Why the study?
Does the distribution of cardiac output differ between young spontaneously hypertensive rats and normotensive controls?
Does the distribution of cardiac output differ between young spontaneously hypertensive rats and normotensive controls?
Early in the development of hypertension in the SHR model, vascular resistance rises uniformly across the peripheral circulation without altering regional cardiac output distribution.
Uniform resistance increase preserves organ perfusion distribution in early SHR hypertension; leaves open translation to human disease.
Radioactive microspheres (50 µmdiameter) were injected into the left ventricle of conscious rats fasted for 12 h, and the percent distribution of cardiac output to major organs was determined in young female (8–9 weeks of age) spontaneously hypertensive rats (SHR) and in age- and sex-matched Wistar Kyoto (WKY) normotensive controls. Systolic arterial blood pressure was elevated (p < 0.001) in the unanesthetized SHR (140 ± 4) compared to the WKY (112 ± 3). There was no significant difference in the percent distribution of cardiac output to the kidneys, heart, stomach, small and large intestines, liver, lungs, adrenals and limbs between the SHR and WKY. The data suggest that early in the development of high blood pressure, a uniform rise in vascular resistance exists throughout the peripheral circulation of the young SHR.
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Tobia et al. (2008) studied this question.
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