Population
Transiently transfected tsA201 cells
Design
Preclinical
Authors
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Subunit interactions in L-type calcium channels leave open domain-targeted modulator design; human and in vivo validation required before clinical consideration.
The study demonstrates that the extracellular domains of the alpha2delta subunit are essential for assembly with the alpha1 subunit and for increasing ligand binding affinity in voltage-dependent calcium channels.
Gurnett et al. (1997) studied this question.
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