Why the study?
Does dystrophin deficiency alter the sliding velocity of actomyosin in mouse diaphragm muscle?
Does dystrophin deficiency alter the sliding velocity of actomyosin in mouse diaphragm muscle?
Dystrophin deficiency in mdx mice is associated with reduced actomyosin sliding velocity and altered myosin heavy chain composition in the diaphragm muscle.
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Should not change DMD management; hypothesis-generating for actomyosin dysfunction in dystrophin-deficient diaphragm weakness.
Coirault et al. (2002) studied this question.
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